Safety of Morphine in anterior acute ST-segment elevation myocardial infarction (STEMI)

Effect and Safety of Morphine Use in Acute Anterior ST‐Segment Elevation Myocardial Infarction

BACKGROUND Morphine is commonly used to treat chest pain during myocardial infarction, but its effect on cardiovascular outcome has never been directly evaluated. The aim of this study was to examine the effect and safety of morphine in patients with acute anterior ST-segment elevation myocardial infarction followed up for 1 year. METHODS AND RESULTS We used the database of the CIRCUS (Does C...

ST-Segment Elevation in Acute Myocardial Infarction

Four hundred and four patients who were admitted to the hospital with their first myocardial infarction within 24 hours of the onset of symptoms were studied. In 315 patients the ECG findings in 12 standards leads (I, II, aVF, aVR, aVL, V,-V6) showed the infarction to be in the anterior wall, the inferior wall, or in multiple areas. The patients in each of these three categories were further su...

Tenecteplase: Innovative Fibrinolysis for ST-Segment Elevation Myocardial Infarction (STEMI)

The use of fibrinolytic agents in the early treatment of ST-segment elevation myocardial infarction (STEMI) is known to significantly reduce mortality. Accelerated (“frontloaded”) alteplase is being challenged as the standard of care for pharmacological reperfusion. Alteplase, reteplase, and streptokinase have several limitations. The search for newer agents has focused on developing a fibrinol...

Myocardial Hemorrhage After Acute Reperfused ST-Segment–Elevation Myocardial Infarction

Efficacy of clotinab in acute myocardial infarction trial-ST elevation myocardial infarction (ECLAT-STEMI).

BACKGROUND This study investigated the efficacy and the safety of the upstream glycoprotein (Gp) IIb/IIIa inhibitor (clotinab; ISU ABXIS, Seoul, Republic of Korea) under 600-mg clopidogrel pretreatment compared with provisional use in ST-elevation myocardial infarction (STEMI). METHODS AND RESULTS A total of 786 STEMI patients were randomized to upstream use in the emergency room (ER) (n = 39...